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selected a priori an interval of six hours from headache onset to
computed tomography as determined by our consensus group, consisting of
five emergency physicians and one neurosurgeon, based on the available
evidence and on temporal trends towards prioritising neuroimaging and
technical improvements in imaging.Outcome measuresPatients were deemed
to be positive for subarachnoid haemorrhage if they had any of
subarachnoid blood identified on unenhanced head computed tomography;
visible xanthochromia in the cerebrospinal fluid; or red blood cells
(>5106/L) in the final tube of cerebrospinal fluid collected and an
aneurysm identified on cerebral angiography (digital subtraction,
computed tomography, or magnetic resonance angiography).24Qualified
local radiologists (a neuroradiologist or general radiologist who
routinely reports head computed tomography images), who were blinded to
the study and data forms but who had routine clinical information,
interpreted all computed tomograms.
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Participants thus were volunteers, were not paid, and were not
recruited to the study as would be the case for a clinical trial. Vissa
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